Publications

Pre-Prints:

Olusakin, J, Kumar, G, Basu, M, Calarco, CA, Fox, ME, Alipio, JB, Haga, C, Turner,MD, Keller,A, Ament, SA, Lobo, MK. Sex-specific transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice. bioRxiv : https://doi.org/10.1101/2022.11.18.517129

Peer-Reviewed:

2022

Morais-Silva, G, Campbell, RR, Nam, H, Basu, M, Pagliusi M, Fox, ME, Chan, CS, Iñiguez, SD, Ament, SA, Cramer, N, Marin, MT, Lobo, MK. Molecular, circuit, and stress response characterization of Ventral Pallidum Npas1-neurons. J Neurosci. 2022. In press


Fox ME*, Wulff AB, Franco D, Choi EY, Calarco CA, Engeln M, Turner MD, Chandra R, Rhodes VM, Thompson SM, Ament SA, Lobo MK*. Adaptations in nucleus accumbens neuron subtypes mediate negative affective behaviors in fentanyl abstinence. Biol. Psychiatry 2022. doi: 10.1016/j.biopsych.2022.08.023 * denotes co-corresponding author


Engeln M, Fox ME, Chandra R, Choi EY, Nam H, Qadir H, Thomas S, Rhodes VM, Turner MD, Herman RJ, Calarco CA, Lobo MK. Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward. Mol. Psychiatry 2022. doi:10.1038/s41380-022-01668-7


Pagliusi Jr M, Franco D, Cole S, Morais-Silva G, Chandra R, Fox ME, Iñiguez SD, Sartori CR, Lobo MK. The BDNF-TrkB pathway acts through nucleus accumbens D2 expressing neurons to mediate stress susceptible outcomes. Front. Psychiatry. 2022 (13):854494. doi: 10.3389/fpsyt.2022.854494


Franco,D, Wulff,AB, Lobo,MK, Fox ME. Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice. Front. Behav. Neurosci. 2022 (16):821080. doi: 10.3389/fnbeh.2022.821080

2021

Calarco CA, Fox ME, Van Terheyden S, Turner MD, Alipio JB, Chandra R, Lobo MK. Mitochondria-Related Nuclear Gene Expression in the Nucleus Accumbens and Blood Mitochondrial Copy Number after Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice. Front. Psychiatry. 2021 (12):1910. doi:10.3389/fpsyt.2021.737389

Alipio JB, Haga C, Fox ME, Arakawa K, Balaji R, Cramer N, Lobo MK, Keller A. Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior. J Neurosci. 2021 Jan 14;. doi: 10.1523/JNEUROSCI.2470-20.2020.

Engeln M*, Fox ME*, Lobo MK. Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress. Psychopharmacology (Berl). 2021 Jan;238(1):41-54. doi: 10.1007/s00213-020-05657-y. *denotes co-first author

Uddin O, Jenne C, Fox ME, Arakawa K, Keller A, Cramer N. Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. Pharmacol Biochem Behav. 2021 Jan;200:173077. doi: 10.1016/j.pbb.2020.173077.

Alipio JB, Brockett AT, Fox ME, Tennyson SS, deBettencourt CA, El-Metwally D, Francis NA, Kanold PO, Lobo MK, Roesch MR, Keller A. Enduring consequences of perinatal fentanyl exposure in mice. Addict Biol. 2021 Mar;26(2):e12895. doi: 10.1111/adb.12895.

2020

Fox ME, Figueiredo A, Menken MS, Lobo MK. Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat. Sci Rep. 2020 Jul 24;10(1):12393. doi: 10.1038/s41598-020-69339-7.

Engeln M, Mitra S, Chandra R, Gyawali U, Fox ME, Dietz DM, Lobo MK. Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration. Biol Psychiatry. 2020 Jun 1;87(11):992-1000. doi: 10.1016/j.biopsych.2019.10.019.

Engeln M, Song Y, Chandra R, La A, Fox ME, Evans B, Turner MD, Thomas S, Francis TC, Hertzano R, Lobo MK. Individual differences in stereotypy and neuron subtype translatome with TrkB deletion. Mol Psychiatry. 2020 May 4;. doi: 10.1038/s41380-020-0746-0.

Fox ME, Chandra R, Menken MS, Larkin EJ, Nam H, Engeln M, Francis TC, Lobo MK. Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior. Mol Psychiatry. 2020 May;25(5):1022-1034. doi: 10.1038/s41380-018-0211-5.

Fox ME. Aversion No MOR: Mu-opioid receptors in habenular β4 neurons are key for naloxone aversion. Neuropsychopharmacology. 2020 Jan;45(2):243-244. doi: 10.1038/s41386-019-0404-x.

2019

Fox ME, Lobo MK. The molecular and cellular mechanisms of depression: a focus on reward circuitry. Mol Psychiatry. 2019 Dec;24(12):1798-1815. doi: 10.1038/s41380-019-0415-3.

Francis TC, Gaynor A, Chandra R, Fox ME, Lobo MK. The Selective RhoA Inhibitor Rhosin Promotes Stress Resiliency Through Enhancing D1-Medium Spiny Neuron Plasticity and Reducing Hyperexcitability. Biol Psychiatry. 2019 Jun 15;85(12):1001-1010. doi: 10.1016/j.biopsych.2019.02.007. Epub 2019 Feb 13.

2018

Engeln M*, Fox ME*, Lobo MK. Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions. Neuron. 2018 May 2;98(3):459-461. doi: 10.1016/j.neuron.2018.04.016. *denotes co-first author

2017

Fox ME, Rodeberg NT, Wightman RM. Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal. Neuropsychopharmacology. 2017 Feb;42(3):671-681. doi: 10.1038/npp.2016.135.

Fox ME, Wightman RM. Contrasting Regulation of Catecholamine Neurotransmission in the Behaving Brain: Pharmacological Insights from an Electrochemical Perspective. Pharmacol Rev. 2017 Jan;69(1):12-32. doi: 10.1124/pr.116.012948.

2016

Fox ME, Bucher ES, Johnson JA, Wightman RM. Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis. ACS Chem Neurosci. 2016 Dec 21;7(12):1681-1689. doi: 10.1021/acschemneuro.6b00210.

Fox ME, Mikhailova MA, Bass CE, Takmakov P, Gainetdinov RR, Budygin EA, Wightman RM. Cross-hemispheric dopamine projections have functional significance. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6985-90. doi: 10.1073/pnas.1603629113.

2015

Fox ME, Studebaker RI, Swofford NJ, Wightman RM. Stress and Drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function. Neuropsychopharmacology. 2015 Jun;40(7):1752-61. doi: 10.1038/npp.2015.23.

2014

Dankoski EC, Agster KL, Fox ME, Moy SS, Wightman RM. Facilitation of serotonin signaling by SSRIs is attenuated by social isolation. Neuropsychopharmacology. 2014 Dec;39(13):2928-37. doi: 10.1038/npp.2014.162.

Bucher ES, Fox ME, Kim L, Kirkpatrick DC, Rodeberg NT, Belle AM, Wightman RM. Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab. 2014 Jul;34(7):1128-37. doi: 10.1038/jcbfm.2014.60.

2013

McElligott ZA, Fox ME, Walsh PL, Urban DJ, Ferrel MS, Roth BL, Wightman RM. Noradrenergic synaptic function in the bed nucleus of the stria terminalis varies in animal models of anxiety and addiction. Neuropsychopharmacology. 2013 Aug;38(9):1665-73. doi: 10.1038/npp.2013.63.